The role of habituation in hippocampus‐dependent spatial working memory tasks: Evidence from GluA1 AMPA receptor subunit knockout mice
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چکیده
منابع مشابه
The role of habituation in hippocampus-dependent spatial working memory tasks: Evidence from GluA1 AMPA receptor subunit knockout mice
Spatial alternation, win-shift behavior has been claimed to be a test of working memory in rodents that requires active maintenance of relevant, trial-specific information. In this review, we describe work with GluA1 AMPA receptor subunit knockout mice that show impaired spatial alternation, but normal spatial reference memory. Due to their selective impairment on spatial alternation, GluA1 kno...
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Genetically modified mice, lacking the GluA1 AMPA receptor subunit, are impaired on spatial working memory tasks, but display normal acquisition of spatial reference memory tasks. One explanation for this dissociation is that working memory, win-shift performance engages a GluA1-dependent, non-associative, short-term memory process through which animals choose relatively novel arms in preferenc...
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ژورنال
عنوان ژورنال: Hippocampus
سال: 2010
ISSN: 1050-9631,1098-1063
DOI: 10.1002/hipo.20896